1-Piperidinecarboxylic acid, 4-cyano-4-(cyclopropylmethyl)-, 1,1-dimethylethyl ester
1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine
CAS: 895132-31-7
Molecular Formula: C15H24N2O2
1-Piperidinecarboxylic acid, 4-cyano-4-(cyclopropylmethyl)-, 1,1-dimethylethyl ester - Names and Identifiers
1-Piperidinecarboxylic acid, 4-cyano-4-(cyclopropylmethyl)-, 1,1-dimethylethyl ester - Physico-chemical Properties
| Molecular Formula | C15H24N2O2 |
| Molar Mass | 264.36 |
| Density | 1.08±0.1 g/cm3(Predicted) |
| Boling Point | 381.9±35.0 °C(Predicted) |
| pKa | -3.09±0.40(Predicted) |
1-Piperidinecarboxylic acid, 4-cyano-4-(cyclopropylmethyl)-, 1,1-dimethylethyl ester - Introduction
1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine is an organic compound with a 4-cyano-4-(cyclopropylmethyl) piperidine group and a Boc protecting group (tert-butoxycarbonyl) in its molecular structure. The following is a description of some properties, uses, preparation and safety information about the substance:
Nature:
-Appearance: A white solid or crystalline powder
-Molecular formula: C16H24N2O2
-Molecular weight: 276.37g/mol
-Melting point: about 53-57°C
-Boiling point: about 378.7°C
Use:
1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine is a commonly used organic synthesis intermediate with many applications, including drug synthesis, ligand synthesis, material chemistry, etc. Specific uses are as follows:
-Drug synthesis: commonly used in the synthesis of various drugs and bioactive compounds.
-Complex synthesis: It can be used to synthesize metal complexes, such as catalysts and metal organic frameworks.
-Material chemistry: It can be used as an intermediate for the synthesis of polymer materials and other organic materials.
Preparation Method: The preparation method of
1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine is relatively simple, and a commonly used synthetic route is as follows:
1.4-cyano-4-(cyclopropylmethyl) piperidine was reacted with di-tert-butyldifluoromethylsilane (TBS-Cl) to give 4-benzyl -4-(cyclopropylmethyl) piperidine.
2.4-benzyl -4-(cyclopropylmethyl) piperidine is reacted with tert-butyryl chloride (Boc-Cl) to obtain 1-Boc-4-benzyl -4-(cyclopropylmethyl) piperidine.
3. Finally, 1-Boc-4-benzyl-4-(cyclopropylmethyl) piperidine was reacted with sodium cyanide to remove the benzyl group to give the final product 1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine.
Safety Information:
- 1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine has low toxicity to humans under routine operations and is generally non-irritating to the skin and eyes.
-During use, it is recommended to take appropriate protective measures, such as wearing gloves and glasses, and avoid direct contact with the compound.
-When performing large-scale synthesis or operation, it is recommended to perform it in a well-ventilated laboratory, and follow relevant safe operating procedures and use appropriate working conditions.
- 1-Boc-4-Cyano-4-(Cyclopropylmethyl)-The Piperidine should be stored in a sealed container, away from heat sources and open flames, and avoid contact with oxidants.
Nature:
-Appearance: A white solid or crystalline powder
-Molecular formula: C16H24N2O2
-Molecular weight: 276.37g/mol
-Melting point: about 53-57°C
-Boiling point: about 378.7°C
Use:
1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine is a commonly used organic synthesis intermediate with many applications, including drug synthesis, ligand synthesis, material chemistry, etc. Specific uses are as follows:
-Drug synthesis: commonly used in the synthesis of various drugs and bioactive compounds.
-Complex synthesis: It can be used to synthesize metal complexes, such as catalysts and metal organic frameworks.
-Material chemistry: It can be used as an intermediate for the synthesis of polymer materials and other organic materials.
Preparation Method: The preparation method of
1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine is relatively simple, and a commonly used synthetic route is as follows:
1.4-cyano-4-(cyclopropylmethyl) piperidine was reacted with di-tert-butyldifluoromethylsilane (TBS-Cl) to give 4-benzyl -4-(cyclopropylmethyl) piperidine.
2.4-benzyl -4-(cyclopropylmethyl) piperidine is reacted with tert-butyryl chloride (Boc-Cl) to obtain 1-Boc-4-benzyl -4-(cyclopropylmethyl) piperidine.
3. Finally, 1-Boc-4-benzyl-4-(cyclopropylmethyl) piperidine was reacted with sodium cyanide to remove the benzyl group to give the final product 1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine.
Safety Information:
- 1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine has low toxicity to humans under routine operations and is generally non-irritating to the skin and eyes.
-During use, it is recommended to take appropriate protective measures, such as wearing gloves and glasses, and avoid direct contact with the compound.
-When performing large-scale synthesis or operation, it is recommended to perform it in a well-ventilated laboratory, and follow relevant safe operating procedures and use appropriate working conditions.
- 1-Boc-4-Cyano-4-(Cyclopropylmethyl)-The Piperidine should be stored in a sealed container, away from heat sources and open flames, and avoid contact with oxidants.
Last Update：2024-04-09 21:00:56
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